|
KMID : 0356419930110020129
|
|
Journal of Korean Andrology
1993 Volume.11 No. 2 p.129 ~ p.134
|
|
|
A Case of Male Infertility Secondary to Congenital Adrenal Hyperplasia
|
|
|
|
|
Abstract
|
|
|
Congenital adrenal hyperplasia, a deficiency of an adrenal enzyme involved in the biosynthesis of cortisol, is a recognized cause of infertility. Abnormal adrenal steroid production inhibits the release of gonadotropins by the
hypothalamic-hypophyseal
axis, resulting in failure of normal testicular maturation. We have studied a male patient with congenital adrenal hyperplasia secondary to 21-hydroxylase deficiency who presented with infertility. After he had received 7 weeks of steroid
treatment, his
wife became pregnant. Suppression of gonadotropin secretion due to overproduction of adrenal androgens would appear to be the reason for the failure of testicular maturation and spermatogenesis in this patient. We conclude that glucocorticoid
treatment
is indicated I infertile men suffering from congenital aerenal hyperplasia and that late-onset congenital adrenal hyperplasia should be suspected in any male infertility of unknown origin.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|